Name STEARYLDISULFIDEHEXYL SH-DNA-2 PEG-45/SH-RNA-1 Description Stearyldisulfidehexyl sh-DNA-2 PEG-45/sh-RNA-1 is a synthetic human RNA strand conjugated with a synthetic human complementary DNA strand modified at the 5' end with Stearyldisulfidehexyl and at the 3' end with polyethylene glycol. The RNA is an androgen-receptor-specific siRNA comprised of 19 ribonucleotides. The modified DNA is a complementary strand comprised of 19 deoxyribonucleotides selected from the isoform-common region of human androgen receptor mRNAs isoform 1. This was developed for effective and specific degradation of mRNA coding androgen receptor. Benefits HAIR CONDITIONING Considerations • Ethoxylated Chemical This is an ethoxylated chemical, meaning it’s been created with ethylene oxide, traces of which, along with its carcinogenic byproduct, 1,4-dioxane, can remain in the product.
• Endocrine Disruption
PEGs have been associated with reproductive toxicity and xenoestrogenic properties. Research Sources https://link.springer.com/article/10.1007/s12595-021-00412-3#:~:text=Among%20other%20EDCs%20in%20personal,health%20especially%20on%20female%20reproduction https://www.epa.gov/assessing-and-managing-chemicals-under-tsca/final-risk-evaluation-14-dioxane Summary Contamination concerns (carcinogenic ethylene oxide and/or 1,4-dioxane), suspected endocrine disruption.
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