Name Sodium PCA Description Sodium PCA is short for sodium pyroglutamic acid, aka pyrrolidone carboxylic acid. It is the sodium salt of pyroglutamic acid, a derivative of the amino acid proline. It is used as a humectant and skin conditioner in cosmetic formulas and can be derived or synthesized from petroleum, plant, or animal sources. Benefits Sodium PCA is used as a humectant and moisturizing agent in cosmetic formulas. It has NOT been found to be a reproductive or endocrine toxin. It is also NOT a photo-toxin or corrosive eye irritant.
Despite the compound's synthetic origins, it is actually a natural component of our skin's acid mantle or moisture barrier. Sodium pyroglutamic acid can help mimic the skin's natural barrier and soothe skin from inflammation. Considerations • Nitrosamine Contamination
In the presence of certain chemicals and in heat and light, sodium PCA can break down and react to create carcinogenic nitrosamines. • Skin Absorption Sodium PCA has been found to be absorbed through the skin; it's estimated that 1% of the concentration of sodium PCA is able to reach the bloodstream. It is believed that the body metabolizes it to glutamic acid, an amino acid that the body uses in many basic functions. • Skin Irritation Sodium PCA can be a skin irritant in rare situations. Synonyms 54571-67-4
sodium 5-oxopyrrolidine-2-carboxylate
2-Pyrrolidone-5-carboxylic acid sodium salt
Sodium pyrrolidone carboxylate
Sodium PCA
PCA Soda
Sodium 5-oxo-DL-prolinate
Ajidew N-50
DL-Sodium pyroglutamate
Sodium DL-pyroglutamate
Monosodium 5-oxoproline
sodium;5-oxopyrrolidine-2-carboxylate
sodium dl-pyrrolidonecarboxylate
5-Oxo-DL-proline, monosodium salt
sodium 2-pyrrolidone-5-carboxylate
DL-Proline, 5-oxo-, monosodium salt
469OTG57A2
Proline, 5-oxo-, sodium salt (1:1)
Nalidone
Proline, 5-oxo-, monosodium salt
C5H6NNaO3
UNII-469OTG57A2
EINECS 259-234-9
DL-SODIUM PIDOLATE
SCHEMBL66285
PIDOLATE SODIUM, DL-
sodium5-oxopyrrolidine-2-carboxylate
SODIUM DL-PYROGLUTAMATE [WHO-DD]
SODIUM PYRROLIDONE CARBOXYLATE [II]
SODIUM PYRROLIDONE CARBOXYLATE [VANDF]
PYRROLIDONE CARBOXYLIC ACID, SODIUM SALT
Q27258924
5-Oxo-L-proline monosodium salt;Sodium pyroglutamate;L-PCA-NA;Sodium PCA Research Sources https://thedermreview.com/sodium-pca/ https://www.cir-safety.org/sites/default/files/pca.pdf
https://journals.sagepub.com/doi/abs/10.1177/109158189901800206 https://pubchem.ncbi.nlm.nih.gov/compound/23666346 Summary Can be contaminated with carcinogenic nitrosamines and enter the skin.
Where Knowledge Grows