Name Polysorbate 80 Description Polysorbate 80 is an emulsifier, surfactant, fragrance ingredient, and skin conditioning agent.
Polysorbate, a substance formulated by the reaction of sorbitan fatty acid ester (a nonionic surfactant) with ethylene oxide. It acts as an emulsifier, a solubilizer in many foods, including bread, cake mix, salad dressing, shortening oil and chocolate. Polysorbate 80 is a hydrophilic nonionic surfactant used in many types of cosmetic items. Benefits Combines water and oil. Considerations • Ethoxylated Chemical
Polysorbate 80 is an ethoxylated chemical, meaning it’s been created with ethylene oxide, traces of which, along with its carcinogenic byproduct, 1,4-dioxane, can remain in the product.
• May Interfere with Medications
Polysorbate 80 may inhibit potential cytochrome P450 enzymes. These enzymes are responsible for breaking down many substances, including drugs, in the body. Inhibiting these enzymes may affect how medications are metabolized in your body, leading to potentially harmful effects. • Disrupts the Gut
When ingested, polysorbate 80 can disrupt the gut barrier, leading to inflammation and dysbiosis. Dishwashing soaps that leave polysorbate 80 residue may cause gut barrier damage. • Skin Irritation
Polysorbate 80 can be a skin irritant. • Degradation Concerns
Polysorbate 80 can be unstable and may require antioxidants or preservatives to keep it stable from oxidation. When polysorbate 80 breaks down it releases hydroperoxides, which break down and create free radicals. • Immune Reaction
Polysorbate 80 and other polysorbates can cause severe immune reactions. Synonyms 6OZP39ZG8H
Monitan
Sorbimacrogol oleate 300
Armotan PMO-20
Atlox 1087
Capmul POE-O
Crillet 4
Drewmulse poe-smo
Durfax 80
Emsorb 6900
Ethoxylated sorbitan monooleate
MO 55F
Montanox 80
NCI-C60286
Polyethylene glycol 300 sorbitan monooleate
Polyethylene oxide sorbitan mono-oleate
Polyoxyethylene (5) sorbitan monooleate
Polyoxyethylene 20 sorbitan monooleate
Polyoxyethylene sorbitan oleate
Polysorban 80
Protasorb O-20 Research Sources https://pubmed.ncbi.nlm.nih.gov/17973307/ https://pubmed.ncbi.nlm.nih.gov/32171713/ https://pubchem.ncbi.nlm.nih.gov/substance/447275859 https://pubmed.ncbi.nlm.nih.gov/21220010/
https://pubmed.ncbi.nlm.nih.gov/37530764/ https://pubmed.ncbi.nlm.nih.gov/16400901/ https://www.parchem.com/siteimages/attachment/ghs%20polysorbate%2080%20msds.pdf
https://www.jacionline.org/article/S0091-6749(22)01477-4/fulltext Summary Ethoxylated chemical can be contaminated with carcinogenic ethylene oxide and/or 1,4-dioxane.