Name

POLYSORBATE 61

We recommend avoiding

Considerations

• Ethoxylated Chemical Polysorbate 61 is an ethoxylated chemical, meaning it’s been created with ethylene oxide, traces of which, along with its carcinogenic byproduct, 1,4-dioxane, can remain in the product. • May Interfere with Medications Polysorbate 61 may inhibit potential cytochrome P450 enzymes. These enzymes are responsible for breaking down many substances, including drugs, in the body. Inhibiting these enzymes may affect how medications are metabolized in your body, leading to potentially harmful effects. • Disrupts the Gut When ingested, polysorbate 61 can disrupt the gut barrier, leading to inflammation and dysbiosis. Dishwashing soaps that leave polysorbate 61 residue may cause gut barrier damage. • Skin Irritation Polysorbate 61 can be a skin irritant. • Degradation Concerns Polysorbate 61 can be unstable and may require antioxidants or preservatives to keep it stable from oxidation. When polysorbate 21 breaks down it releases hydroperoxides, which break down and create free radicals. • Immune Reaction Polysorbate 61 and other polysorbates can cause severe immune reactions.

Synonyms

Polysorbate 60 [USAN:INN:BAN:NF] 3453J8557N X61U1UH01B 073G38N8GC HD40WR33LC 90SOR12GHG CAL22UVI4M 9005-67-8 Sorbitan, monostearate polyoxyethylene deriv. CCRIS 702 FEMA No. 2916 Glycosperse S-20 Peg sorbitan stearate Peg-20 sorbitan stearate Polyoxyethylene 20 sorbitan monostearate Polyoxyethylene sorbitan monostearate Sorbitan, monostearate, polyoxyethylene derivs. PEG-40 Sorbitan stearate Polyoxyethylene-40-sorbitan monostearate Polysorbate 60 Sorbitan, monooctadecanoate, poly(oxy-1,2-ethanediyl) derivs. Tween 60 PEG-6 Sorbitan stearate PEG-60 Sorbitan stearate Polyethylene glycol (3) sorbitan monostearate Polyethylene glycol 300 sorbitan monostearate Polyethylene glycol 3000 sorbitan monostearate Polyethylene glycol 2000 sorbitan stearate PEG-3 Sorbitan stearate Polyoxyethylene (6) sorbitan monostearate Polyoxyethylene (60) sorbitan monostearate Polyoxyethylene (40) sorbitan stearate Polysorbate 61 Sorbimacrogol stearate 300 Polyoxyethylene (20) sorbitan monostearate Polyoxyethylene (3) sorbitan monostearate Polyoxyethylene (4) sorbitan monostearate UNII-HD40WR33LC UNII-90SOR12GHG UNII-3453J8557N UNII-X61U1UH01B UNII-073G38N8GC UNII-CAL22UVI4M Sorbitan monostearate, ethoxylated EC 500-020-4

Research Sources

https://pubchem.ncbi.nlm.nih.gov/compound/Polysorbate%2020 https://pubmed.ncbi.nlm.nih.gov/19041719/ https://pubmed.ncbi.nlm.nih.gov/37530764/ https://pubmed.ncbi.nlm.nih.gov/36464527/ https://pubmed.ncbi.nlm.nih.gov/30758866/ https://pubmed.ncbi.nlm.nih.gov/32171713/ https://pubmed.ncbi.nlm.nih.gov/17973307/ https://www.sciencedirect.com/topics/chemistry/hydroperoxide#:~:text=Hydroperoxides%20are%20unstable%20intermediates%20of,either%20nonradical%20or%20radical%20mechanisms. https://pubmed.ncbi.nlm.nih.gov/16400901/

Summary

Ethoxylated chemical can be contaminated with carcinogenic ethylene oxide and/or 1,4-dioxane.

Where Knowledge Grows