Name Azelaic Acid Description Azelaic acid is a naturally-occurring dicarboxylic acid found in grains such as wheat, barley, and rye. It is commonly used in dermatology for its skin benefits, particularly in treating conditions like acne, rosacea, and hyperpigmentation. Azelaic acid is commonly manufactured by oxidative cleavage of oleic acid (obtained from grease or tallow) with chromic acid, nitric acid or
by ozonolysis. Azelaic Acid is considered an active drug ingredient in most products and usually only available by prescription. Benefits Azelaic acid has antibacterial, anti-inflammatory, and keratolytic (exfoliating) properties. It works by preventing the growth of skin bacteria that cause acne and by keeping pores clear. It can also be used as a treatment for rosacea and eczema, due to its anti-inflammatory properties. Some research suggests that it can fight cancerous cells, including melanoma cells. Considerations • Skin Irritation
Can cause skin irritation under certain conditions.
• Eye Irritation
Can cause eye irritation or damage at high concentrations.
• Skin Penetration
Known to be able to penetrate skin and enter the bloodstream. 2.2% of a 20% azelaic acid formula was found in urine after dermal application.
• Blood-Brain Barrier
Azelaic acid can cross the blood-brain barrier. However, dietary intake accounts for most azelaic acid levels in the body. And it may offer antioxidant benefits.
• Skin Photosensitivity
Exposure to the sun after application of azelaic acid treatments may result in accelerated sunburn. Synonyms Azelaic acid
NONANEDIOIC ACID
Anchoic acid
Lepargylic acid
1,7-Heptanedicarboxylic acid
Skinoren
1,9-Nonanedioic acid
Heptanedicarboxylic acid
n-Nonanedioic acid
azelate
acide azelaique
acidum azelaicum
Acido azelaico
Azelainic acid
1,7-Dicarboxyheptane
Azelaic acid, technical grade
Acidum azelaicum [Latin]
Azelainsaeure
Nonandisaeure
Azalaic Acid
Acide azelaique [French]
Acido azelaico [Spanish]
heptane-1,7-dicarboxylic acid
Nonanedioic acid Azelaic acid
Water-soluble azelaic acid
Dicarboxylic acid C9
Nonanedioic acid
AZA Research Sources https://pubmed.ncbi.nlm.nih.gov/32730109/
https://pubchem.ncbi.nlm.nih.gov/compound/2266
https://www.cir-safety.org/ingredient/azelaic-acid Summary Naturally-occurring in many foods, azelaic acid is generally safe as used in cosmeceuticals, phototoxicity and skin irritation being the main risks.