Considerations

• Penetration Enhancer 1,2-hexanediol is a well-known penetration enhancer, meaning that it has the ability to cross the skin's barrier and allow other chemicals along with it. • Oxidative Damage While it's considered to have a low-toxicity (ie it doesn't make you sick or immediately kill you upon ingestion) it is broken down in the body through oxidation, a process that may release free radicals. • Acute Toxicity From a study: [I]f 1,2-hexanediol enters the human body either via oral intake or through an open wound, it could have critical effects. Furthermore, upon release into the environment, 1,2-hexanediol could cause considerable damage to plants and other organisms. Therefore, further investigation of 1,2-hexanediol is required to prevent toxicity to humans and other living organisms. • Eye Irritation 1,2-hexanediol is known to be a strong eye irritant. • Ethical Concerns It is NOT known to be a carcinogen or reproductive toxin. However, 1-hexene, the chemical that 1,2-hexanediol is made from, is a carcinogen. This may exposure workers to harmful conditions.