Name POLYSORBATE 85 Description Sorbitan, ethoxylated, mono-9-(Z)-octadecenoate, acetate (20 mol EO average molar ratio) Benefits SURFACTANT – CLEANSING, SURFACTANT – EMULSIFYING Considerations • Ethoxylated Chemical
Polysorbate 81 is an ethoxylated chemical, meaning it’s been created with ethylene oxide, traces of which, along with its carcinogenic byproduct, 1,4-dioxane, can remain in the product.
• May Interfere with Medications
Polysorbate 21 may inhibit potential cytochrome P450 enzymes. These enzymes are responsible for breaking down many substances, including drugs, in the body. Inhibiting these enzymes may affect how medications are metabolized in your body, leading to potentially harmful effects. • Disrupts the Gut
When ingested, polysorbate 21 can disrupt the gut barrier, leading to inflammation and dysbiosis. Dishwashing soaps that leave polysorbate 21 residue may cause gut barrier damage. • Skin Irritation
Polysorbate 21 can be a skin irritant. • Degradation Concerns
Polysorbate 21 can be unstable and may require antioxidants or preservatives to keep it stable from oxidation. When polysorbate 21 breaks down it releases hydroperoxides, which break down and create free radicals. • Immune Reaction
Polysorbate 21 and other polysorbates can cause severe immune reactions. Synonyms Polysorbate 85
Tween 85
A7F3N56197
ALKAMULS PSTO-20
CCRIS 703
Emsorb 6903
Glycosperse TO-20
JEESORB TO-20
Liposorb TO-20
POLYOXYETHYLENE 20 SORBITAN TRIOLEATE (COMPOUND USUALLY CONTAINS ALSO ASSOCIATED FATTY ACIDS)
POLYOXYETHYLENE SORBITAN TRIOLEATE (20E.O.)
Polyoxyethylene (20) sorbitan trioleate
Polyoxyethylene 20 sorbitan trioleate
Protasorb TO-20
SORBAX PTO-20
SORBON T-85
Sorbimacrogol trioleate 300
Sorbitan, tri-9-octadecenoate, poly(oxy-1,2-ethanediyl) derivs.
Sorbitan, trioleate polyoxyethylene deriv.
UNII-A7F3N56197 Research Sources https://pubchem.ncbi.nlm.nih.gov/compound/Polysorbate%2020 https://pubmed.ncbi.nlm.nih.gov/19041719/
https://pubmed.ncbi.nlm.nih.gov/37530764/
https://pubmed.ncbi.nlm.nih.gov/36464527/
https://pubmed.ncbi.nlm.nih.gov/30758866/ https://pubmed.ncbi.nlm.nih.gov/32171713/
https://pubmed.ncbi.nlm.nih.gov/17973307/
https://www.sciencedirect.com/topics/chemistry/hydroperoxide#:~:text=Hydroperoxides%20are%20unstable%20intermediates%20of,either%20nonradical%20or%20radical%20mechanisms. https://pubmed.ncbi.nlm.nih.gov/16400901/ Summary Ethoxylated chemical can be contaminated with carcinogenic ethylene oxide and/or 1,4-dioxane.