Name

POLYSORBATE 81

We recommend avoiding

Considerations

• Ethoxylated Chemical Polysorbate 81 is an ethoxylated chemical, meaning it’s been created with ethylene oxide, traces of which, along with its carcinogenic byproduct, 1,4-dioxane, can remain in the product. • May Interfere with Medications Polysorbate 81 may inhibit potential cytochrome P450 enzymes. These enzymes are responsible for breaking down many substances, including drugs, in the body. Inhibiting these enzymes may affect how medications are metabolized in your body, leading to potentially harmful effects. • Disrupts the Gut When ingested, polysorbate 81 can disrupt the gut barrier, leading to inflammation and dysbiosis. Dishwashing soaps that leave polysorbate 81 residue may cause gut barrier damage. • Skin Irritation Polysorbate 81 can be a skin irritant. • Degradation Concerns Polysorbate 81 can be unstable and may require antioxidants or preservatives to keep it stable from oxidation. When polysorbate 21 breaks down it releases hydroperoxides, which break down and create free radicals. • Immune Reaction Polysorbate 81 and other polysorbates can cause severe immune reactions.

Synonyms

Polysorbate 81 2MSF640LWM ETHSORBOX O-5 JEESORB O-5 PEG-5 SORBITAN OLEATE POLYOXYETHYLENE(5)SORBITAN MONOOLEATE SORBAX PMO-5

Research Sources

https://pubchem.ncbi.nlm.nih.gov/compound/Polysorbate%2020 https://pubmed.ncbi.nlm.nih.gov/19041719/ https://pubmed.ncbi.nlm.nih.gov/37530764/ https://pubmed.ncbi.nlm.nih.gov/36464527/ https://pubmed.ncbi.nlm.nih.gov/30758866/ https://pubmed.ncbi.nlm.nih.gov/32171713/ https://pubmed.ncbi.nlm.nih.gov/17973307/ https://www.sciencedirect.com/topics/chemistry/hydroperoxide#:~:text=Hydroperoxides%20are%20unstable%20intermediates%20of,either%20nonradical%20or%20radical%20mechanisms. https://pubmed.ncbi.nlm.nih.gov/16400901/

Summary

Ethoxylated chemical can be contaminated with carcinogenic ethylene oxide and/or 1,4-dioxane.