Name POLYSORBATE 40 Considerations • Ethoxylated Chemical
Polysorbate 40 is an ethoxylated chemical, meaning it’s been created with ethylene oxide, traces of which, along with its carcinogenic byproduct, 1,4-dioxane, can remain in the product.
• May Interfere with Medications
Polysorbate 40 may inhibit potential cytochrome P450 enzymes. These enzymes are responsible for breaking down many substances, including drugs, in the body. Inhibiting these enzymes may affect how medications are metabolized in your body, leading to potentially harmful effects. • Disrupts the Gut
When ingested, polysorbate 40 can disrupt the gut barrier, leading to inflammation and dysbiosis. Dishwashing soaps that leave polysorbate 21 residue may cause gut barrier damage. • Skin Irritation
Polysorbate 40 can be a skin irritant. • Degradation Concerns
Polysorbate 40 can be unstable and may require antioxidants or preservatives to keep it stable from oxidation. When polysorbate 21 breaks down it releases hydroperoxides, which break down and create free radicals. • Immune Reaction
Polysorbate 40 and other polysorbates can cause severe immune reactions. Synonyms Polysorbate 40
Polyoxyethylene 20 sorbitan monopalmitate
STI11B5A2X
Polyoxyethylene (20) sorbitan monopalmitate
Polyoxyethylene sorbitan monopalmitate
Sorbimacrogol palmitate 300
CHEBI:53423
Crill 7
Crillet 2
Durfax 60
Emsorb 6910
Ethoxylated sorbitan monopalmitate
Glycosperse p-20
Nissan Nonion PT-221
Polyethylene glycol sorbitan monopalmitate
Polyethylene glycol-sorbitan monopalmitate adduct
Sorbitan monopalmitate polyethylene glycol ether
Sorbitan polyethoxy monopalmitate
Sorbitan, monopalmitate, polyoxyethylene derivs
CCRIS 701
E-434
HSDB 1928
INS NO.434
INS-434
POLYSORBATE 40 (EP MONOGRAPH)
POLYSORBATE 40 (II)
POLYSORBATE 40 (MART.)
POLYSORBATE 40 (USP-RS)
Polyethylene glycol (80) sorbitan monopalmitatey
Radiasurf 7145
SORBITAN, MONOHEXADECANOATE, POLY(OXY-1,2-ETHANEDIYL) DERIVS
Sorbitan, monopalmitate polyoxyethylene deriv.
UNII-4NR71FN0IA
UNII-STI11B5A2X Research Sources https://pubchem.ncbi.nlm.nih.gov/compound/Polysorbate%2020 https://pubmed.ncbi.nlm.nih.gov/19041719/
https://pubmed.ncbi.nlm.nih.gov/37530764/
https://pubmed.ncbi.nlm.nih.gov/36464527/
https://pubmed.ncbi.nlm.nih.gov/30758866/ https://pubmed.ncbi.nlm.nih.gov/32171713/
https://pubmed.ncbi.nlm.nih.gov/17973307/
https://www.sciencedirect.com/topics/chemistry/hydroperoxide#:~:text=Hydroperoxides%20are%20unstable%20intermediates%20of,either%20nonradical%20or%20radical%20mechanisms. https://pubmed.ncbi.nlm.nih.gov/16400901/ Summary Ethoxylated chemical can be contaminated with carcinogenic ethylene oxide and/or 1,4-dioxane.