Name

POLYSORBATE 40

We recommend avoiding

Considerations

• Ethoxylated Chemical Polysorbate 40 is an ethoxylated chemical, meaning it’s been created with ethylene oxide, traces of which, along with its carcinogenic byproduct, 1,4-dioxane, can remain in the product. • May Interfere with Medications Polysorbate 40 may inhibit potential cytochrome P450 enzymes. These enzymes are responsible for breaking down many substances, including drugs, in the body. Inhibiting these enzymes may affect how medications are metabolized in your body, leading to potentially harmful effects. • Disrupts the Gut When ingested, polysorbate 40 can disrupt the gut barrier, leading to inflammation and dysbiosis. Dishwashing soaps that leave polysorbate 21 residue may cause gut barrier damage. • Skin Irritation Polysorbate 40 can be a skin irritant. • Degradation Concerns Polysorbate 40 can be unstable and may require antioxidants or preservatives to keep it stable from oxidation. When polysorbate 21 breaks down it releases hydroperoxides, which break down and create free radicals. • Immune Reaction Polysorbate 40 and other polysorbates can cause severe immune reactions.

Synonyms

Polysorbate 40 Polyoxyethylene 20 sorbitan monopalmitate STI11B5A2X Polyoxyethylene (20) sorbitan monopalmitate Polyoxyethylene sorbitan monopalmitate Sorbimacrogol palmitate 300 CHEBI:53423 Crill 7 Crillet 2 Durfax 60 Emsorb 6910 Ethoxylated sorbitan monopalmitate Glycosperse p-20 Nissan Nonion PT-221 Polyethylene glycol sorbitan monopalmitate Polyethylene glycol-sorbitan monopalmitate adduct Sorbitan monopalmitate polyethylene glycol ether Sorbitan polyethoxy monopalmitate Sorbitan, monopalmitate, polyoxyethylene derivs CCRIS 701 E-434 HSDB 1928 INS NO.434 INS-434 POLYSORBATE 40 (EP MONOGRAPH) POLYSORBATE 40 (II) POLYSORBATE 40 (MART.) POLYSORBATE 40 (USP-RS) Polyethylene glycol (80) sorbitan monopalmitatey Radiasurf 7145 SORBITAN, MONOHEXADECANOATE, POLY(OXY-1,2-ETHANEDIYL) DERIVS Sorbitan, monopalmitate polyoxyethylene deriv. UNII-4NR71FN0IA UNII-STI11B5A2X

Research Sources

https://pubchem.ncbi.nlm.nih.gov/compound/Polysorbate%2020 https://pubmed.ncbi.nlm.nih.gov/19041719/ https://pubmed.ncbi.nlm.nih.gov/37530764/ https://pubmed.ncbi.nlm.nih.gov/36464527/ https://pubmed.ncbi.nlm.nih.gov/30758866/ https://pubmed.ncbi.nlm.nih.gov/32171713/ https://pubmed.ncbi.nlm.nih.gov/17973307/ https://www.sciencedirect.com/topics/chemistry/hydroperoxide#:~:text=Hydroperoxides%20are%20unstable%20intermediates%20of,either%20nonradical%20or%20radical%20mechanisms. https://pubmed.ncbi.nlm.nih.gov/16400901/

Summary

Ethoxylated chemical can be contaminated with carcinogenic ethylene oxide and/or 1,4-dioxane.