Name Methylisothiazolinone Description Methylisothiazolinone is used as a preservative and biocide in cosmetics, textiles, paints, emulsions, and glues. Methylisothiazolinone is produced by chlorination of dimethyl dithiodipropionamide in solvent, then neutralized and extracted into water and purified. It is restricted to a .01% concentration in cosmetic products. Benefits Prevents bacterial growth. Considerations • Neurotoxin
In vitro and in vivo studies have found that methylisothiazolinone displays neurotoxic activity. Animals exposed to MIT in development were found to have seizures, reduced physical abilities, and loss of vision. • Endocrine Disruption
Animal studies have found MIT affects the thyroid and endocrine system. • Skin And Eye Irritation
At higher concentrations can cause skin and eye irritation and damage. • Acute Toxicity
Can damage organs through prolonged or repeated exposure. • Fatal if Inhaled
Fumes of methylisothiazolinone can be deadly.
• Toxic to Aquatic Life
Known to be persistent and toxic in the environment. Synonyms 2-Methyl-4-isothiazolin-3-one
Methylisothiazolinone
2-Methyl-3(2H)-isothiazolone
2-methylisothiazol-3(2h)-one
2-Methyl-4-isothiazoline-3-one
3(2H)-Isothiazolone, 2-methyl-
N-Methyl-3-oxodihydroisothiazole
N-METHYL-3-OXODIHYDRO ISOTHIAZOLE
2-methyl-3-isothiazolone
2-METHYL-2H-ISOTHIAZOL-3-ONE
MIT
2-methyl-1,2-thiazol-3(2H)-one
MIT Research Sources https://jpet.aspetjournals.org/content/317/3/1320.abstract
https://pubmed.ncbi.nlm.nih.gov/22245758/ https://pubmed.ncbi.nlm.nih.gov/34915294/
https://pubchem.ncbi.nlm.nih.gov/compound/39800 https://cir-reports.cir-safety.org/view-attachment/?id=9ddfbb4a-63e3-d43c-a0a5-2de6fdee91c3 Summary Neurotoxin, endocrine disruptor, irritant, acute toxicity.
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