Name Hydroxyapatite Description Hydroxyapatite is a crystalline compound made from calcium and phosphorous. Our bones and teeth are comprised primarily of hydroxyapatite. It is currently being used in oral care products. Benefits There are some claims that hydroxyapatite in oral care can remineralize teeth, especially if it's nano-sized. Considerations • Illegal Claims
No hydroxyapatite product has gone through the drug approval process to legally make remineralizing claims. The efficacy and safety of hydroxyapatite has not been fully studied. • Bioaccumulation
Nano hydroxyapatite can accumulate in tissues and organs if one has experienced systemic exposure. Brain, kidneys, liver, and lungs seem to the the organs most affected. • Inflammation
Nano hydroxyapatite can cause inflammation in the body. It has been shown to calcify artery walls. It may also cause kidney stones. • Genotoxicity
Nano hydroxyapatite has been found, like many nanoparticles, to be genotoxic. DNA damage and inflammation can induce carcinogenesis. • Gut Health
Nano hydroxyapatite can disrupt gut health. See notes for further discussion. Synonyms Durapatite
Hydroxylapatite
1306-06-5
Calcium hydroxyapatite
Tribasic calcium phosphate
Durapatite [USAN]
Calcium hydroxide phosphate
Calcium hydroxylapatite
Calcium tribasic phosphate
Dekacalcium-dihydrat-hexa(phosphat)
calcium hydroxide tris(phosphate)
pentacalcium;hydroxide;triphosphate
Decacalcium hexaphosphate dihydroxide
Pentacalcium hydroxide tris(orthophosphate)
HYDROXYLAPATITE, CERAMIC
CALCIUM PHOSPHATE,TRIBASIC
Calcium phosphate, tribasic [NF]
EC 235-330-6
CALCIUM PHOSPHATE (TRIBASIC)
Durapatite (USAN)
Apatite, hydroxy
Supertite 10
HYDROXYAPATITE (MART.)
HYDROXYAPATITE [MART.]
Calcium phosphate, tribasic (NF)
pentacalcium hydroxide triphosphate
TRIBASIC CALCIUM PHOSPHATE (II)
TRIBASIC CALCIUM PHOSPHATE [II]
Hydroxylapatite (Ca5(OH)(PO4)3)
Calcium orthophosphate, basic
TRIBASIC CALCIUM PHOSPHATE (USP-RS)
TRIBASIC CALCIUM PHOSPHATE [USP-RS]
Hydroxyapatite, Calcium
EINECS 215-145-7
Pentacalcium monohydroxyorthophosphate
hydroxyl apatite Research Sources https://ec.europa.eu/health/scientific_committees/consumer_safety/docs/sccs_o_191.pdf?fbclid=IwAR3LghPye_lKL5xvDmPrzdK16af4zuK3rm9Cx8XOfievneBen3xjbclkWKQ
https://pubmed.ncbi.nlm.nih.gov/37633389/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10640876/ https://www.tandfonline.com/doi/10.2217/nnm-2017-0329?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub++0pubmed
https://pubchem.ncbi.nlm.nih.gov/compound/14781 https://pubmed.ncbi.nlm.nih.gov/25625290/ Summary Avoid nano hydroxapatite. Non-nano is likely safe.
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